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This isolate was judged to be resistant because the acyclovir IC 50 was >10-fold higher than the IC 50 for the control sensitive strain! 12 In the case of KS, coumadin classification in which discharge planning has begun, the most practical therapy would be the selection of an oral antimicrobial agent, which in this case would be either nitrofurantoin or fosfomycin! This medication passes into breast milk and may harm a nursing infant!